It's a pain but it's a fact that if you have a family's member that have ovarian cancer history, then you MAY get that disease too. But not only that, if one of your family's member have breast cancer history, it can increase your percentage of getting ovarian cancer.
The fact is approximately 90% of ovarian cancers happen by chance, 10% of women with ovarian cancer have succeed genetic changes that tend them to ovarian cancer. There are three hereditary syndromes that affect to ovarian cancer:
1. Hereditary breast-ovarian cancer syndrome due to mutations in the tumor suppressor genes BRCA1 and BRCA2
Approximately 10% of women with ovarian cancer are bearers of a breast/ovarian cancer sensitivity gene. The proportion of cases of ovarian cancer appropriate to such a gene decreases with age and is estimated to be 14% for women diagnosed in the fourth decade, going down to 7% for women diagnosed in the sixth decade.
2. Hereditary Non-Polyposis Colorectal Cancer (Lynch syndrome II)
Hereditary Non-Polyposis Colorectal Cancer (HNPCC), also called Lynch syndrome II, is a hereditary syndrome most average marked by an increased risk for colorectal cancer. The lifetime risk of colorectal cancer is 80%, and is especially diagnosed in the individual's mid-40s. The risk of endometrial (uterine) cancer related with HNPCC is approximately 40%, while the risk of ovarian cancer is 10%. Other related cancers include biliary tract, urinary tract, small bowel and stomach.
3. Hereditary site-specific ovarian cancer.
Limited data are available on the site-specific ovarian cancer syndrome. This is the least average of the three hereditary cancer syndromes, and is marked by an increased risk of ovarian cancer. Findings from one group of investigators recommended that most families with this syndrome are associated to mutations in the BRCA1 gene.
Source:
>> Ovariancancer.jhmi.edu
Image:
>> sxc.hu
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